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Nanomedicine Journal، جلد ۷، شماره ۲، صفحات ۱۰۸-۱۱۴
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عنوان انگلیسی Docetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies
چکیده انگلیسی مقاله Objective(s): Folate-targeted liposomes have been well considered in folate receptor (FR) overexpressing cells including MCF-7 and 4T1 cells in vitro and in vivo. The objective of this study is to design an optimum folate targeted liposomal formulations which show the best liposome cell uptake to tumor cells.Material and Methods: In this study, we prepared and characterized different targeted formulations and a nontargeted form as a control. Physicochemical analysis showed that the liposomes had homogeneous population and appropriate size to accumulate to tumor sites through the enhanced permeation and retention (EPR) mechanism. Moreover, we compared the cell uptake of folate targeted liposomal docetaxel compared to nontargeted liposomes in vitro. Results: The in vitro drug release profile of the formulations at different time points showed none of the formulations did not has burst release. However, targeted liposomes accumulated in tumor tissue in vivo less than nontargeted formulations which could be attributed to their uptake by RES due to relatively greater size of targeted formulations. It is presumable that analyze the biodistribution process at longer time points and the molecular mechanisms behind the tissue accumulation could clear the issue. Conclusion: We conclude that success in vitro studies holds the promise of folate targeting strategy and in vivo study merits further investigations.
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نویسندگان مقاله | Roghayyeh Vakili-Ghartavol
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mahmoud Reza Jaafari
Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran


| Amin Reza Nikpoor
Molecular Medicine Research Center Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Seyed Mahdi Rezayat
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran|Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://nmj.mums.ac.ir/article_14009.html
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