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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۵۶۹-۵۷۵
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عنوان انگلیسی Evaluation of the anti-oxidant effect of ascorbic acid on apoptosis and proliferation of germinal epithelium cells of rat testis following malathion-induced toxicity
چکیده انگلیسی مقاله Objective(s): The aim of this study was to determine the protective role of ascorbic acid on apoptosis and proliferation of spermatogonia and primary spermatocyte cells after malathion administration as an organophosphate pesticide in rat testis.Materials and Methods: Thirty male Wistar rats were randomly divided into five groups of 6 rats each, including control (no intervention), sham (normal saline 0.09%), malathion (50 mg/kg), malathion plus ascorbic acid (50 mg/kg and 200 mg/kg, respectively), and ascorbic acid (200 mg/kg) groups. Malathion and ascorbic acid were administrated via intraperitoneal injection once per day and seven times per week. After 6 weeks, animals were sacrificed, and testis tissue was used for evaluation of apoptosis and proliferation of germinal epithelium cells using the TUNEL and PCNA staining techniques. Results: The results of TUNEL staining showed that the numbers of apoptotic cells in spermatogonia and primary spermatocyte cells were significantly increased in the malathion 50 mg/kg group vs control group (P
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نویسندگان مقاله | Faezeh Ghorbani-Taherdehi
Department of Anatomy and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohammad Reza Nikravesh
Department of Anatomy and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahdi Jalali
Department of Anatomy and Cell Biology, Mashhad University of Medical Sciences, Mashhad, Iran


| Alireza Fazel
Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahmoud Gorji Valokola
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15197.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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