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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۵، صفحات ۶۵۴-۶۶۲
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عنوان انگلیسی Relationship between calcium circulation-related factors and muscle strength in rat sciatic nerve injury model
چکیده انگلیسی مقاله Objective(s): The purpose of this study is to investigate the indication function of the calcium circulation-related factors on the damage to muscle strength and contraction function after nerve injury. The target factors include ryanodine receptor (RyR), inositol-1,4,5-triphosphate receptor (IP3R), phospholamban (PLN), cryptocalcitonin (CASQ), ATPase and troponin C (TNNC).Materials and Methods: Sprague-Dawley (SD) rats were randomly divided into sham-operated group (SO), sciatic nerve injury group (SNI) and sciatic nerve disconnection group (SNT). Sciatic nerve function index and stretching test were used to examine the changes to muscle strength; bilateral gastrocnemius muscles were extracted after execution for gastrocnemius wet weight ratio test. HE staining slides and average cross-sectional area of muscle fibers were acquired to analyze the muscle atrophy. The transcription level of the factors was also measured.Results: Sciatic nerve damage in SNI group was significantly higher than that in SO group in the 6 weeks, but there was no significant difference between SNT and SO groups fallowing sciatic nerve damage. Sciatic nerve function in SNT group was worse than that in SNI group. The average cross-sectional area of gastrocnemius muscle fibers in SNI and SNT groups was significantly reduced compared to that in SO group. The transcriptional levels of RyR, PLN, CASQ, ATPase and TNNC in SNI and SNT groups were significantly different from those in SO group.Conclusion: Calcium circulation-related factors could be used as potential indicators for assessment of damages to muscle strength.
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نویسندگان مقاله | Xiaoming Sun
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Wei Wang
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Yangyi Dong
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Yue Wang
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Meixiang Zhang
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Zhao Wang
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Xiaowei Yu
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Jiao Huang
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China


| Hongxing Cai
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_15230.html
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زبان مقاله منتشر شده en
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