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Journal of Reproduction and Infertility، جلد ۲۱، شماره ۲، صفحات ۸۷-۹۴
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عنوان انگلیسی A Study on the Presence of Osteopontin and α3β1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation
چکیده انگلیسی مقاله Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of endometrium. The aim of the current study was to evaluate the effects of diabetes on osteopontin (OPN) and α3β1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazone-treated and metformin-treated groups. Western blot was performed to determine the OPN and α3β1 integrin proteins in rats' endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p< 0.05 was considered statistically significant. Results: OPN increased significantly in the diabetic group in comparison with control (p< 0.001), metformin-treated (p=0.008) and pioglitazone-treated groups (p< 0.001). Furthermore, α3β1 integrin protein level in diabetic group had a significant difference in comparison with that of the control (p< 0.001), metformin-treated (p=0.026) and pioglitazone-treated groups (p< 0.001). Conclusion: OPN and α3β1 integrin proteins are involved in embryo implantation and their changes in diabetic condition can affect fertility. Treatment with pioglitazone and metformin improved the level of OPN and α3β1 integrin proteins while pioglitazone was more effective.
کلیدواژه‌های انگلیسی مقاله Diabetes mellitus, Endometrium, Osteopontin, α3β1 integrin
نویسندگان مقاله | Yasaman Zarrin
Isfahan Medical Student Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Abbas Bakhteyari
Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Parvaneh Nikpour
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran


| Fatemeh Sadat Mostafavi
Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Nahid Eskandari
Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Mohammad Matinfar
Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


روشنك ابوترابي | Roshanak Aboutorabi
Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://www.jri.ir/article/60074
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