این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۱۴، شماره ۲، صفحات ۱-۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antioxidant and Hypolipidemic Effects of Methanolic Root Extract of Chromolaena odorata in Alloxan-induced Diabetic Rats
چکیده انگلیسی مقاله Background: Chromolaena odorata (C. odorata) is a medicinal plant with hypoglycemic effect known in traditional medicine. The present study investigated the in vitro antioxidant and in vivo anti-hyperglycemic effect of the methanol root extract of C. odorata in rats. Methods: Phytochemical compositions were evaluated, using standard procedures while the antioxidant activities were examined, using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing power (FRAP) assays. Twenty albino rats were administered 120mg/kg of body weight (bw) alloxan and were divided into four groups of five animals each. Groups A to D were treated with 2ml/kg of normal saline, 300 mg/kg, 500 mg/kg bw extract and 5 mg/kg bw glibenclamide, respectively, through oral route for 14 days. Blood samples were collected and prepared for the analysis of serum lipids profile. Results: The extract contained tannins (54.76±4.08mg/100g), saponins (322.78±17.35mg/100g), glycosides, alkaloids (74.34±6.08mg/100g), flavonoids (79.63±4.55 mg/100g), phenols (154.32±11.21 mg/100g), glycosides, steroids and reducing sugar. The extract promoted the inhibition of DPPH radicals with IC50 values of 191.68±1.68 µg/mL. In comparison with the untreated controls, total cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides were significantly reduced (p< 0.05) following treatment with C. odorata extract while high density lipoprotein (HDL)-cholesterol, was significantly increased. Conclusions: The C. odorata extract exhibited antioxidant and hypolipidemic effects in alloxan-induced diabetic rat, thus could be considered as a natural product in the management of dyslipidemia secondary to diabetes.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Oluyemisi Omotayo Omonije
PhD Student, Department of Biochemistry, Federal University of Technology, P.M.B.65, Minna, Nigeria.


| Abubakar Ndaman Saidu
Department of Biochemistry, Federal University of Technology, P.M.B. 65, Minna, Nigeria.


| Hadiza Lami Muhammad
Department of Biochemistry, Federal University of Technology, P.M.B. 65, Minna, Nigeria.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-612-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات