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Iranian Journal of Toxicology، جلد ۱۴، شماره ۲، صفحات ۲-۲
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عنوان انگلیسی Histomorphometrical and Stereological Study of the Lungs in Neonatal Rats Born to Paraquat-poisoned Pregnant Rats: Protective Effect of Coenzyme Q10
چکیده انگلیسی مقاله Background: Paraquat (PQ), an herbicide, is a very poisonous compound for both humans and animals. This study was conducted to examine the protective effect of the Coenzyme Q10 (CoQ10) in newborn rats from pregnant rats pre-treated with PQ. Methods: The experiments were conducted on 25 rats, divided in five groups randomly and equally: 1 - Control Group received normal saline (0.1ml/day); 2 - PQ Group received PQ only (5 mg/kg/day); 3 – PQ + CoQ10 Group received PQ (5mg/kg) and CoQ10 (10mg/kg) daily; 4 – PQ + olive oil Group received PQ (5mg/kg) and olive oil (10mg/kg) daily; 5 - Olive oil Group received olive oil (10 mg/kg/day). All of the injections were made intraperitoneally and started on the 16th day of pregnancy through to parturition. Sixteen days after parturition, the lungs were removed from the newborn rats, paraffin sections were made and stained with hematoxylin and eosin, and analyzed histomorphometrically and stereologically. Results: The results revealed that interstitial tissue and lung alveoli had normal structures in the control and olive oil groups. In PQ and PQ-olive oil groups alveolar hemorrhage, inflammation, extensive fibrosis, decreased alveolar numbers, increased mast cells, and changes in the epithelia were observed. In PQ-CoQ10 Group there was a significant recovery in all of the histological alterations. Conclusion: Generally, Coenzyme Q10 had a protective effect against lung damages caused by PQ, but a complete recovery of the damaged lung tissue would probably take longer than 16 days after birth.
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نویسندگان مقاله فاطمه بالازاده کوچه | Fatemeh Balazadeh koucheh
PhD Student, Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University. Urmia, Iran.
دانشکده دامپزشکی

رسول شهروز | Rasoul Shahrooz
Professor of Histology, Division of Histology & Embryology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University. Urmia, Iran.
دانشکده دامپزشکی

علی شالیزار جلالی | Ali Shalizar Jalali
Associate Professor of Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University. Urmia, Iran
دانشکده دامپزشکی

حمید کریمی | Hamid Karimi
Associate Professor of Anatomy, Department of Basic Sciences, Faculty of Veterinary Medicine, Tabriz University. Tabriz, Iran
دانشکده دامپزشکی

الهام زاده هاشم | Elham Zadeh Hashem
Assistant Professor of Toxicology, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University. Urmia, Iran
دانشکده دامپزشکی

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-581-1&slc_lang=en&sid=1
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