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Middle East Journal of Cancer، جلد ۱۱، شماره ۲، صفحات ۱۷۴-۱۸۴
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عنوان انگلیسی Does Vitamin E Mitigate Cisplatin-induced Nephrotoxicity in Cancer Patients: Results from a Randomized Placebo-Controlled Clinical Trial
چکیده انگلیسی مقاله Background: Cisplatin (CP) is a potent antineoplastic agent in the treatment of wide a range of cancers, but it is accompanied with nephrotoxicity, a major limiting side effect. The aim of the present study was to evaluate the possible protective effect of vitamin E in the prevention of CP-induced nephrotoxicity. Method: In this randomized clinical trial, a total of 51 patients treated with CP chemotherapy were randomly assigned to receive vitamin E supplementation (400 Iu/ daily) (N=26) or placebo (N=25). Serum creatinine, glomerular filtration rate (GFR), and neutrophil gelatinase-associated lipocalin were measured prior to each chemotherapy cycle and one month after the cessation of the cycles. Result: Compared to the baseline, a significant decrease was observed in the blood levels of neutrophil gelatinase-associated lipocalin and serum creatinine in the vitamin E group (P=0.001). GFR was not reduced in the vitamin E group (P=0.001), and vitamin E was generally tolerated well. Conclusion: Our findings indicated that vitamin E exert protective effects against CP-induced nephrotoxicity, a finding which requires larger studies for confirmation.
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نویسندگان مقاله Farzaneh Ashrafi |
Department of Hematology and Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Naeimi Tabiei |
Department of Hematology and Oncology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Sarah Mousavi |
Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Mehdi Nematbakhsh |
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Parisa Sotoodehnasab |
School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Ghasem Janbabaei |
Department of Hematology and Oncology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://mejc.sums.ac.ir/article_46421_aeed3c0d39df36500fa852d3c14fd4ed.pdf
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