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The Archives of Bone and Joint Surgery، جلد ۸، شماره Covid-۱۹ Special Issue، صفحات ۰-۰
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عنوان انگلیسی Molecular Aspects Of Co-Morbidities In COVID-19 Infection
چکیده انگلیسی مقاله Coronaviruses are a group of enveloped viruses with positive-sense RNA genomes that are non-segmented and single-stranded. In December 2019, SARS-CoV-2 appeared in China for the first time and quickly spread across the world. There is no vaccination or approved drug available for this virus yet, although certain medications suggested for other afflictions tend to be potentially effective for curing the infection. Comprehension of the disease's molecular pathogenesis could provide useful tools for COVID-19 patients in surveillance, prognosis, treatment, vaccine development and therapeutic targeting. The present research aims to summarize the association in COVID-19 patients between molecular dimensions of comorbidities with clinical and preclinical information. Developing an ACE2 inhibitor could be a possible therapeutic target. Plasmin is another possible candidate both in diagnosis and treatment areas. All predicted biomarkers must be validated either through randomized clinical trials or through experimental assays before being used in patients.
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نویسندگان مقاله | Mohammad Amin Kerachian
Mashhad University of Medical Sciences, Faculty of Medicine, Department of Medical Genetics


| Farzaneh Pouya
Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Zeynab Imani Saber
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://abjs.mums.ac.ir/article_15447.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/328/article-328-2376100.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده CURRENT CONCEPTS REVIEW
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