این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Digestive Diseases، جلد ۱۲، شماره ۲، صفحات ۱۰۶-۱۱۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Comparison between 10-day and 12-day Concomitant Regimens for Helicobacter Pylori Eradication: A Randomized Clinical Trial
چکیده انگلیسی مقاله ABSTRACT BACKGROUND: Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide, which is associated with peptic ulcer disease and gastric cancer. In this study, we compared the efficacy of 10-day versus 12-day concomitant therapy as the first-line treatment for H. pylori eradication in Iran. METHODS: 218 patients with peptic ulcer disease and naïve H. pylori infection, were randomly divided into two groups to receive either 10-day or 12-day concomitant regimens, composed of pantoprazole 40 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and metronidazole 500 mg, all given twice daily. Eight weeks after treatment, H. pylori eradication was assessed by 14 C- urea breath test. The trial was registered in the Iranian Registry of Clinical Trials (code: IRCT20170521034070N2). RESULTS: 212 patients completed the study. According to the intention to treat analysis, the eradication rates were 83.6% (95% CI: 76.6-90.5) and 88.8% (95% CI: 82.8-94.7) in 10-day and 12-day concomitant therapy groups, respectively ( p =0.24). Per-protocol eradication rates were 85.9% (95% CI: 79.3–92.4) and 92.6% (95% CI: 87.6–97.5), respectively ( p =0.19). The rates of severe side effects were not statistically different between the two groups (3.6% vs. 8.1%; p =0.428). CONCLUSION: 12-day concomitant therapy could achieve ideal eradication rates by both intention to treat and per-protocol analyses. In order to reduce the cost of drugs and the rate of adverse effects of therapy, among 10-day and 12day regimens, 12-day concomitant therapy seems to be a good alternative to 14-day concomitant therapy that has been suggested by international guidelines
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Zohreh Bari
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.


| Hafez Fakheri
Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.


| Tarang Taghvaei
Assistant Professor of Medicine, Division of Gastroenterology, Mc Master University, Hamilton ON, Canada


| Mohammad Yaghoobi


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2131
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/332/article-332-2376133.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات