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Acta Medica Iranica، جلد ۵۷، شماره ۹، صفحات ۵۴۹-۵۵۳
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عنوان انگلیسی Lower circulating levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and chromium in treated Brucella infection
چکیده انگلیسی مقاله Objective: Brucellosis is a common infectious disease around the globe. The aim of the present investigation was to evaluate the effect of brucellosis on the levels of chromium (Cr), lead (Pb), soluble TNF–like weak inducer of apoptosis (sTWEAK) as well as high-sensitivity C-reactive protein (hs-CRP) and homocysteine in the serum of subjects suffering from brucellosis. Materials and methods: The present case-control study was executed on 40 treated brucellosis patients (case) and 40 healthy individuals (control). Blood samples were obtained from all the participants for the measurement of the desired indices. Results: The serum levels of chromium in the case group (0.109 ± 0.025 μg/L) was significantly lower compared with that in the control group (0.121 ± 0.027 μg/L, P = 0.047). The levels of lead in serum were almost unchanged between the two groups (12.58 ± 1.94 vs. 12.28 ± 2.42 μg/dL, P = 0.533). The sTWEAK levels were significantly lower in case group as compared to the control subjects (235.20 ± 48.45 pg/mL vs. 262.00 ± 67.25 pg/mL, P = 0.044). The levels of hs-CRP were significantly higher in the case group (2.23 ± 0.34 mg/L) than that in the control group (2.05 ± 0.32 mg/L, P = 0.016); similarly, homocysteine levels were higher in the serum of patients in case group as compared to the control ones (16.18 ± 4.47 µmol/L vs. 14.36 ± 3.06 µmol/L, P = 0.038). Conclusion: The current investigation underlined that brucellosis causes alterations in serum chromium and sTWEAK levels, the markers that are considered as the predictors of cardiovascular disease.
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نویسندگان مقاله | Mohamad Mohsenpour Azari


| Bahram Golestani Eimani
Department of Biology, Urmia Branch, Islamic Azad University, Urmia, Iran


| Rasoul Entezarmahdi


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/8004
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