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Iranian Biomedical Journal، جلد ۲۴، شماره ۴، صفحات ۲۳۶-۲۴۲
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عنوان انگلیسی Enhanced Adipose Mesenchymal Stem Cells Proliferation by Carboxymethyl-Chitosan Functionalized Polycaprolactone Nanofiber
چکیده انگلیسی مقاله Background: Through combining two synthetic and natural polymers, scaffolds can be developed for tissue engineering and regenerative medicine purposes. Methods: In this work, CMC (20%) was grafted to PCL nanofibers using the cold atmospheric plasma of helium. The PCL scaffolds were exposed to CAP, and functional groups were developed on the PCL surface. Results: The results of FTIR confirmed CMC (20%) graft on PCL scaffold. The MTT assay showed a significant enhancement (p < 0.05) in the cell affinity and proliferation of ADSCs to CMC20%-graft-PCL scaffolds. After 14 days, bone differentiation was affirmed through alizarin red and calcium depositions. Conclusion: Based on the results, the CMC20%-graft-PCL can support the proliferation of ADSCs and induce the differentiation into bone with longer culture time.
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نویسندگان مقاله | Atena Shapourzadeh
Department of Biochemistry, Faculty of Basic Science, Islamic Azad University Damghan Branch, Damghan, Iran


| Seyed Mohammad Atyabi
Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran 13164, Iran


| Shiva Irani
Science and Research Branch, Islamic Azad University, Tehran, Iran


| Hadi Bakhshi
Universitatsstraße Bayreuth, Germany-Universitatsstraße Bayreuth, Germany
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-817&slc_lang=other&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2380498.pdf
کد مقاله (doi)
زبان مقاله منتشر شده other
موضوعات مقاله منتشر شده Tissue Engineering and Cell Biology
نوع مقاله منتشر شده مقاله کامل
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