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Iranian Biomedical Journal، جلد ۲۴، شماره ۴، صفحات ۲۵۱-۲۵۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum
چکیده انگلیسی مقاله Background: The present study aimed to evaluate the effects of different concentrations of CONPs on the OS status in kidney, lung, and serum of rats. Methods: Male Wistar Rats were treated intraperitoneally with 15, 30,  and 60 mg/kg/day of CONPs. The biochemical parameters, including TAC, TTG, MDA, SOD, and CAT were assayed in serum, kidney, and lung tissues. Results: MDA decreased, but TTG and CAT increased in serum by the administration of CONPs at 15 mg/kg. In kidney homogenate obtained from the group treated with CONPs at 15 mg/kg, TAC, TTG, and CAT significantly increased compared to the control group. However, CONPs at 15, 30, and 60 mg/kg significantly decreased MDA level compared to the control group. In lung tissue, CONPs in doses of 15, 30 and 60 mg/kg significantly decreased CAT activity, TTG and TAC compared to the control group, while in kidney tissue, CONPs at the concentrations of 30 and 60 mg/kg significantly increased MDA compared to the control group. Conclusion: Our findings suggest that CONPs attenuate OS in the kidney and affect the serum levels of OS-related markers but induce OS in the lung tissue in a dose-dependent manner.
کلیدواژه‌های انگلیسی مقاله Kidney, Lung, Nanoparticles, Oxidative stress
نویسندگان مقاله | Adel Sepanjnia
Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran


| Hassan Ghasemi
Department of Clinical Biochemistry, Abadan Faculty of Medical Sciences, Abadan, Iran


| Roohollah Mohseni
Department of Biochemistry, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Akram Ranjbar
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran


| Fatemeh Shabani
Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran


| Fouzieh Salimi
Department of Biomedical Science, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran


| Nejat Kheiripour
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-814&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/125/article-125-2380500.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmaceutical Biotechnology
نوع مقاله منتشر شده مقاله کامل
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