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International Journal of Organ Transplantation Medicine، جلد ۱۱، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Systematic Review of Donor Serum Sodium Level and Its Impact on Transplant Recipients
چکیده انگلیسی مقاله Background: An important aspect of donor management is the optimization of serum sodium levels. Objective: To perform a systematic review to determine the effects of donor sodium levels on heart, lung, kidney, and pancreas graft function, recipient mortality, and to identify the optimal donor serum sodium target. Methods: We searched MEDLINE, Cochrane, Guideline databases, and trial registries from 1946 to May 2019 for studies investigating the effects of donor serum sodium levels on transplant outcomes in all nonhepatic organs. A two-step independent review process was used to identify relevant articles based on inclusion/exclusion criteria. We describe the results narratively, assess the risk of bias, and apply GRADE methodology to evaluate the certainty in the evidence. Results: We included 18 cohort studies in our final analysis (n=28,007). 3 of 4 studies demonstrated an association between donor serum sodium and successful organ transplantation. 5 studies reported no association with graft function, while 6 studies did. 5 studies reported on recipient survival, 3 of which suggested donor sodium is unlikely to be associated with recipient survival. The included studies had serious risk of bias, and the certainty in evidence was deemed to be very low. Conclusion: In low risk of bias studies, donor sodium dysregulation is unlikely to affect kidney graft function or mortality of heart and kidney recipients, but the certainty in the evidence is very low due to inconsistency and imprecision. Further research is required to refine the serum sodium target range, quantify the dose-response curve, and identify organs most vulnerable to sodium dysregulation.
کلیدواژه‌های انگلیسی مقاله Transplantation,Organ donation,Sodium,Brain death
نویسندگان مقاله | J Basmaji
Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada


| L Hornby
Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada and Canadian Blood Services, Ottawa, Ontario, Canada


| B Rochwerg
Division of Critical Care, Department of Medicine, McMaster University, Hamilton, Ontario, Canada and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada


| P Luke
Division of Urology, Department of Surgery, Western University, London, ON, Canada and Matthew Mailing Centre for Translational Transplant Studies, Lawson Research Institute, London Health Sciences Centre, London, Ontario, Canada


| I M Ball
Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
نشانی اینترنتی http://www.ijotm.com/ojs/index.php/IJOTM/article/view/706
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/221/article-221-2386779.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Articles
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