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کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Interaction between LncRNAs and Epigenetic Factors in Gastric Cancer Progression
چکیده انگلیسی مقاله Gastric cancer (GC) is one of the most common malignancies in East Asian countries and the second cause of cancer-related deaths worldwide. Aberrant expression of long non-coding RNAs (lncRNAs) plays a crucial role in the development of GC. These molecules take part in various biological processes such as apoptosis, invasion, cell death markers, reprogramming of pluripotent stem cells, and genomic imprinting, which show that lncRNAs play an essential role in eukaryotic gene expression. LncRNAs interact with epigenetic factors including DNA methylases, histone modifiers, miRNAs, and chromatin remodeling complex, which lead to altered gene expression and cancer progression. Because the symptoms of GC usually develop in advanced stages, it is important to identify factors that are of clinical value for early diagnosis and prognosis of the disease. Therefore, in this review article, lncRNAs whose expression levels are increased in GC tissue and by interacting with epigenetic factors may be involved in the development of GC are discussed. Keywords : LncRNA, epigenetic, and gastric cancer
کلیدواژه‌های انگلیسی مقاله Key words, LncRNA, epigenetic, and gastric cancer.
نویسندگان مقاله | Negin Raei
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran


| Reza Safaralizadeh
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.


| Mohammad Ali Hessein Pour Feizi
Department of Cell and Molecular Biology, University of Mohaghegh Ardabili, Ardabil, Iran.


| Saeid Latifi-Navid
Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.


| Abbas Yazdanbod
Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.


| Farhad Pourfarzi


نشانی اینترنتی http://govaresh.org/index.php/dd/article/view/2149
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زبان مقاله منتشر شده farsi
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نوع مقاله منتشر شده Review Article
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