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Acta Medica Iranica، جلد ۵۷، شماره ۱۱، صفحات ۶۳۵-۶۳۹
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عنوان انگلیسی Association of ADAM33 T1 Polymorphism with subgroups of Pediatric Asthmatic Patients in Iran
چکیده انگلیسی مقاله There is strong evidence on interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 RS2280091 polymorphism and pediatric asthma in Iranian population.  A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification and severity were defined. SNPs of ADAM33 gene at RS2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count and IgE count were also assessed.  T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 RS2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions.
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نویسندگان مقاله | Mir Reza Ghaemi


| Sara Hemmati


| Arezou Rezaei


| Maryam Sadr


| Bahareh Mohebbi


| Hosseinali Ghaffaripour


| Nima Rezaei


| Seyed Alireza Mahdaviani
Pediatric Respiratory Diseases Research Center, National Research Institute Of Tuberculosis And Lung Diseases (NRITLD), Shahid Beheshti University Of Medical Sciences, Tehran , Iran
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/8163
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2410540.pdf
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