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Acta Medica Iranica، جلد ۵۷، شماره ۱۱، صفحات ۶۵۳-۶۵۷
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عنوان انگلیسی Significant burden of nonalcoholic fatty liver disease with advanced fibrosis in people of Iranian origin: a cross-sectional analysis
چکیده انگلیسی مقاله Background and Aim: The main cause of chronic liver disease in Iran is Nonalcoholic fatty liver disease (NAFLD). A common pathological feature of chronic liver disease is fibrosis, so particular vigilance against patients with liver fibrosis is necessary to lead healthcare resource planning. The aims of current study are to determine the prevalence and predictors of significant fibrosis and advanced ones among individuals with NAFLD. Material and Methods: in the current cross sectional study which conducted during 2013-2016, the presence of fibrosis among NAFLD patients was assessed using NAFLD fibrosis score (NFS) and AST to Platelet Ratio Index (APRI) systems. Multivariate logistic regression models were used to predict significant fibrosis or advanced fibrosis among NAFLD patients. Results: Analysis of the results of over 999 patients (569 females and 430 males) with the mean age of 43.28 ± 14.034 years in Iran during 2015-2016 showed that overall prevalence of NAFLD among Iranian adults was 19.6%. NAFLD prevalence was not significantly higher in males compared to females (51.5% vs 48.5%, P=0.66).  On multivariate logistic regression analyses, females were less likely to have NAFLD compared to males (OR 0.32, 95% CI 0.24-0.42, P < 0.001). Overall prevalence of liver fibrosis among NAFLD patients was 38.8%.20.4% and 6.12% of NAFLD patients had evidence of significant and advanced fibrosis respectively. Conclusion: our most recent dataset analyzing emphasized the major burden of NAFLD among people of Iranian origin. So high prevalence of individuals with NAFLD and also advanced fibrosis is estimating.
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نویسندگان مقاله | Ehsan Shahverdi


| Arefeh Ebrahimi


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7783
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