| چکیده انگلیسی مقاله |
Objective(s): Aluminium nitride (AlN) could be used in implantable biomedical sensor devices, for which cytotoxicity analysis is of utmost importance. Materials and Methods: AlN nanoparticles were synthesized using a simple and effective solvothermal method. The X-ray diffraction results revealed the cubic phase of AlN, and the field emission scanning electron microscopy analysis demonstrated the structural morphology of the synthesized materials. In addition, the cytotoxicity of the AlN nanoparticles was assessed against healthy (HEK-293, HUVEC, and MCF10A) and cancerous cell line (HeLa). The intensity of the reactive oxygen species was also measured to determine the induced oxidative stress in the treated cells. Results: The cytotoxicity analysis indicated that the AlN nanoparticles were nontoxic against the cancerous and normal cell lines. No significant changes were observed between the low doses of the AlN nanoparticles in the treated and control cells. However, morphological changes were detected by a phase contrast microscope, while insignificant changes were observed similar to the control cells. Conclusion: The findings of this study could lay the groundwork for the development of AlN nanoparticles for further biomedical applications. |
| نویسندگان مقاله |
| Manjot Kaur
Advanced Functional Material Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India
| Kulwinder Singh
Advanced Functional Material Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India
| Paviter Singh
Advanced Functional Material Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India
| Amanpreet Kaur
Advanced Functional Material Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India|Department of Physics, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India
| Ramovatar Meena
Nanotoxicology Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110 067, India
| Gajendra Pratap Singh
School of Computational and Integrated Sciences, Jawaharlal Nehru University, New Delhi-110 067, India
| Hamed Barabadi
Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Muthupandian Saravanan
Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
| Akshay Kumar
Advanced Functional Material Lab., Department of Nanotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140 407, Punjab, India
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