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Acta Medica Iranica، جلد ۵۸، شماره ۱، صفحات ۱۵-۲۰
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عنوان انگلیسی EFFECT OF CARBOGEN TO CHEMORADIATION IN RECTAL CANCER VOLUME
چکیده انگلیسی مقاله Background: The outcome of inoperable rectal cancer treatment by chemotherapy, radiotherapy and targeted therapy are still unfavorable. Carbogen is a combination of 98% oxygen and 2% carbon dioxide proven effective as chemoradiosensitizer. The aim of this study is to know the effect of concurrent carbogen and chemoradiotherapy in locally advanced rectal cancer by measuring the shrinkage of the tumor volume. Method: The design of this study was randomized true experimental 2 groups pre and post-test-controlled design. Samples were patients with locally advanced rectal cancer. MRI of the pelvis before and 4-8 weeks after the chemoradiation were examined. Results: A total of 28 subjects, 14 patients concurrent chemoradiation with carbogen (treatment group) and 14 patients chemoradiation (control) were included in this study. The tumor shrinkage in the treatment group was significantly higher compared to the control group, the average tumor volume before study was 13.08 cm3 to be 6.08 cm3 in treatment group and 18.00 cm3 to be 12.83 cm3 in control group. Conclusion: Supplementation of carbogen to standard treatment chemoradiation for locally advanced rectal cancer significantly shrinkage the tumor volume.
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نویسندگان مقاله | Christina Nawangsih
Department of Radiology, Diponegoro University


| Soehartati Gondowihardjo
Radiotherapy Department, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital


| Sofia Haryana
Histology Department, Faculty of Medicine, Universitas Gadjah Mada


| Soeharyo Hadisaputro
Internal Medicine Department, Faculty of Medicine, Diponegoro University


| Catharina Suharti
Internal Medicine Department, Faculty of Medicine, Diponegoro University – Kariadi Hospital


| Edi Dharmana
Parasitology Department, Faculty of Medicine, Diponegoro University


| Hermina Sukmaningtyas
Radiology Department, Faculty of Medicine, Diponegoro University – Kariadi Hospital


| Fifin Rahmi
Department of Ophthalmology, Faculty of Medicine, Diponegoro University – Kariadi Hospital


| Ignatius Riwanto
Surgery Department, Faculty of Medicine, Diponegoro University – Kariadi Hospital
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7956
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2445965.pdf
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