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Acta Medica Iranica، جلد ۵۸، شماره ۱، صفحات ۳۲-۳۷
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عنوان انگلیسی Antichlamydia IgG antibody in adult asthmatics in Al-Najaf
چکیده انگلیسی مقاله Background: Infection is presumed to have a rule in promotion of asthma exacerbations and in deterioration of the course of the disease, Chlamydia pneumoniae (C. pneumoniae) is claimed to be a possible cause for these two issues   Aim of the study: to assess the positivity and the titer of C. pneumoniae IgG antibodies in relation to the state of asthma and its severity Patients and Methods: 61 asthmatic patients aged 15-85 years (mean of 47.10  ± 14.887), and 29 apparently healthy, non-asthmatic age and gender matched  volunteers (control group) were assessed as  at Asthma and Allergy clinic in Al-Sader Medical City in AL-Najaf province , Chlamydia Pneumoniae IgG ELISA Kit was used for the detection of IgG antibody to C. Pneumoniae in human serum to detect chronic infection, and Spirometric test was done and the best results for FEV1 and PEFR were taken Results: IgG antichlamydia antibodies was positive in 21(34.4%) of patients compared to 4(13.8%) of controls, and the difference was significant with OR=3.281, the seropositivity in acute exacerbation was  more than in stable asthmatic, 43.8% vs 24.1% (P=0.029), seropositivity was  nonsignificantly more in moderate and severe asthma as compared with mild asthma, a significant inverse correlation between IgG titer and pulmonary function test parameters (FEV1, PEFR) was observed  as the  FEV1&PEFR values decrease with increase IgG titer Conclusions: Chronic C. pneumoniae  infection is common in adult asthmatics and   correlated with  exacerbations & increased severity and disturbed lung function     
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نویسندگان مقاله | Israa Abbas
MBChB, FICMS


| iman kadhim
MBChB, DCM, MsC :teacher, community medicine , medical microbiology


| Suaad Muhammed Rasheed
Teacher: MBChB, MsC, PhD, Medical microbilogy


| falah Deli
Assist Prof, internal medicine: MBChB, FICMS
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7985
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