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Acta Medica Iranica، جلد ۵۸، شماره ۱، صفحات ۳۸-۴۲
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عنوان انگلیسی Griscelli syndrome type 2: A rare case with apparently normal skin and hair pigmentation
چکیده انگلیسی مقاله Griscelli syndrome (GS) is a rare autosomal recessive disease which affects hair, skin and immune system. Here, we describe an 8.5-month-old infant with multiple admissions due to fever, petechial purpura and several recurrent vomiting episodes with a presumptive diagnosis of recurrent sepsis. He was born from parents with consanguineous marriage. The initial examinations revealed huge splenomegaly and hepatomegaly without any source of infection. Laboratory tests revealed a hemophagocytic lymphohistiocytosis (HLH) like picture with high blood level of ferritin in all episodes, but bone marrow test result was normal. Although he had normal hair and skin pigmentation on physical examination, accumulation of melanosomes was found in his hair shafts on microscopic investigations. Eventually, genetic test revealed a mutation in the RAB27A gene which confirmed GS-II diagnosis. Our case is the first case of GS-II from Iran without any apparent clinical features of GS such as hypopigmented skin and silvery-gray hair. Therefore, a genetic test together with the microscopic examination of hair and skin are necessary for the diagnosis and confirmation of GS-II. Since GS-II is an autosomal recessive disorder and consanguineous marriages are popular in Iran, premarital genetic counseling is recommended for this region.
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نویسندگان مقاله | Nima Rezaei


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7825
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2445969.pdf
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