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Acta Medica Iranica، جلد ۵۸، شماره ۱، صفحات ۴۳-۴۶
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عنوان انگلیسی Acute Hemolytic Transfusion Reaction Due to Anti c Rhesus Antibody in a Patient with Subdural Hematoma: A Case Report Emphasizing the Shortcoming of Spin Cross-match
چکیده انگلیسی مقاله Background: Rh blood group system is a complex blood group which includes different antigen specificities such as c antigen. Anti-c antibody is associated with both acute and delayed hemolytic transfusion reactions as well as hemolytic disease of the newborn (HDN). Rh mediated hemolytic transfusion reactions (HTR) are mostly immunoglobulin G (IgG) mediated and results in extravascular hemolysis and delayed HTR (DHTR). However, we are presenting a case of acute intravascular hemolytic transfusion reaction due to Anti c in a patient with acute subdural hematoma. Methods and Materials: A 77-year old woman was referred to our hospital with loss of conscious and left-sided hemiparesia. After an emergency MRI, she was diagnosed with the Acute Subdural hematoma and an emergency craniotomy was performed. Since Acute Subdural hematoma is a neurosurgery emergency, laboratory technician performed an Immediate-spin cross-matched for blood bag to preserve time. During transfusion of the first packed cell, the patient developed a severe hypotension and tachycardia. Thus, the transfusion was stopped. Results: Laboratory results raised the suspicious of an Acute Intravascular Hemolysis. Antibody identification revealed that the patient had an irregular blood phenotype (C2+/c-/E-/e3+/K-) and the presence of alloanti-c Rh antibody confirmed the suspicion of HTR. Conclusion: In patients with multi transfusion history and pregnant women, pre-transfusion screening of irregular antibodies must be performed. The immediate spin cross-match must be prevented in patients with the history of multi transfusions, even in the emergency situations.
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نویسندگان مقاله | Hamid Reza Niazkar
Medical Student, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran


| Mohammad Ghorbani


| Mohsen Saheban Maleki


| Hossein Jahangir


| Farhad Homapour


| Abbasali Abbasnezhad


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/7838
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-2445970.pdf
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