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Research Journal of Pharmacognosy، جلد ۷، شماره ۳، صفحات ۵-۱۳
عنوان فارسی
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عنوان انگلیسی Optimization of Ultrasound-assisted Acidic-solvent Extraction of Colchicine from Colchicum kurdicum (Bornm.) Stef. Using Response Surface Methodology
چکیده انگلیسی مقاله Background and objectives: Colchicum kurdicum (Bornm.) Stef. is a flowering perennial monocotyledon plant that has many important bioactive compounds especially colchicine and colchicine derivatives. In this study, the ultrasound-assisted acidic-solvent extraction method coupled with response-surface method was presented as the successful method for large scale extraction of colchicine as an alkaloid compound from Colchicum kurdicum. Methods: According to the literatures, methanol/deionized water (70:30) solvent system was selected for the extraction. In addition, the response-surface method was used for analysis and optimization of colchicine extraction by ultrasonic-assisted acidic-solvent extraction method. Subsequently, colchicine was extracted using this method and the effects of solvent pH, extraction time, solvent/plant ratio, power, and temperature were evaluated. Results: After all analysis procedures, 0.99 mg colchicine/g dried corms was achieved with the following conditions: solvent pH 4, Extraction time 120 minutes, solvent/plant ratio 20 mL/g, power 100 W, and temperature 60 ºC. Conclusion: According to this study, ultrasonic-assisted acidic-solvent extraction was found an effective method for extraction of colchicine from Colchicum kurdicum (Bornm.) Stef. compared to other extraction methods.
کلیدواژه‌های انگلیسی مقاله colchicine, Colchicum kurdicum, Extraction, HPLC, Ultrasound
نویسندگان مقاله Mohammad Azadbakht |
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Elnaz Khoshvishkaie |
Pharmaceutical Cares Department, Ayatollah Khamenei Hospital, Mazandaran University of Medical Sciences, Abbas Abad, Iran.

Ali Davoodi |
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Seyed Jalal Hosseinimehr |
Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Masoud Azadbakht |
Department of Plant Systematics, High Educational of Sanna Institute, Sari, Iran.

Saeed Emami |
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Hossein Bakhshi Jouybari |
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Fatemeh Mirzaee |
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Kiana Ghadiri |
Active Pharmaceutical Research Centre (APIRC), Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_106223_474d4bcd067bd3a52186d0e30604f630.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-2446189.pdf
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