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Iranian Journal of Otorhinolaryngology، جلد ۳۲، شماره ۴، صفحات ۲۴۹-۲۵۳
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عنوان انگلیسی Sensory-Neural Hearing Loss as an Early Rebound Relapse after Fingolimod Cessation in Multiple Sclerosis
چکیده انگلیسی مقاله Introduction: Multiple sclerosis (MS) is a lifelong disease of the brain and spinal cord. Fingolimod is an oral drug which modulates the S1P receptor and is used for relapsing remitting form of MS and can causes rebound activity if it is ceased even in a short period of washout time. Case Report: Here, we introduce a young girl, a known case of MS, who developed reversible isolated unilateral sensory-neural hearing loss along imaging activity two weeks after stopping fingolimod. The patient responded well to the intravenous corticosteroid therapy which is the first line treatment of new MS attack. Conclusion: fingolimod cessation can cause rebound activity in a short period of the time. It is important to consider any new neurological sign and symptom as a rebound activity during washout time. Although SNHL is not common in MS, it could be presented as an unusual manifestation of rebound relapse after stopping fingolimod. 
کلیدواژه‌های انگلیسی مقاله Fingolimod, Multiple Sclerosis, Rebound activity
نویسندگان مقاله | Abdolreza Naser Moghadasi
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.


| Maryam Poursadeghfard
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Tayebeh Kazemi
Otolaryngology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Samaneh Hosseini
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
نشانی اینترنتی http://ijorl.mums.ac.ir/article_16029.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/11/article-11-2466325.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report
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