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Journal of Basic Research in Medical Sciences، جلد ۹، شماره ۱، صفحات ۱۹-۳۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preconditioning by the exercise and curcumin protects left ventricular myocardium against ischemia-reperfusion injury and suppresses ventricular arrhythmias in rats
چکیده انگلیسی مقاله Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat. Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated. Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001). Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury. Introduction: The present study examined the effects of a 10-week preconditioning with moderate-intensity aerobic exercise and curcumin supplementation before ischemia-reperfusion (IR) to investigate if this method contributes to the protection of cardiac myocardium against IR-induced injury and left ventricular dysfunction in rat. Materials and Methods: Male Wistar rats (6-8 weeks old) were randomly assigned to the 5 groups (each with 10 rats), sedentary-control (Sed-CON), sedentary ischemia-reperfusion (Sed-IR), exercise with IR (Ex-IR), curcumin with IR (Cu-IR), and both exercise and curcumin with IR (Ex-Cu-IR). Exercise intervention performed five times a week for 10 weeks. After the training period, arrhythmias and electrocardiogram parameters, factors involved in cardiac structure and function, and infarct size of myocardium were investigated. Results: We observed that a 10-week moderate-intensity aerobic exercise (15-45 min at 12-24 m/min) five sessions a week as well as curcumin supplementation (50 mg/kg) over the mentioned period, in advance to IR, significantly decreased IR-induced infarct size in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.0001), alleviated arrhythmia by reduction in ventricular ectopic beats episodes in Ex-IR, Cu-IR, and Ex-Cu-IR groups compared to Sed-IR (P = 0.001), decreased ventricular tachycardia episods in Ex-IR, Cu-IR, and Ex-Cu-IR groups in comparison to that of Sed-IR group (P = 0.001) and improved cardiac function (P = 0.001). Conclusion: According to our findings, exercise has superior cardioprotective effects than curcumin. The combination of curcumin and exercise has no preference on exercise or curcumin alone. Hence both long-term aerobic exercise and curcumin supplementation are effective cardioprotectors against IR-induced injury.
کلیدواژه‌های انگلیسی مقاله Antiarrhythmic herbs, Cardioprotection, Moderate-intensity exercise, Reoxygenation injury, Cardiovascular disease
نویسندگان مقاله | Zahra Sayevand
Department of Sport Physiology, Section of Health Science, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran


| Farzad Nazen
Department of Sport Physiology, Section of Health Science, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran


| Afshin Nazari
Razi Herbal Medicines Research Center and Department of Physiology, Lorestan University of Medical Science, Khorramabad, Iran
نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-588-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardiovascular Diseases
نوع مقاله منتشر شده پژوهشی
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