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Journal of Basic Research in Medical Sciences، جلد ۸، شماره ۴، صفحات ۵۰-۵۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats
چکیده انگلیسی مقاله Introduction: The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and expression of peroxisome proliferator-activated receptor 1-alpha (PGC-1α) gene in Wistar rats. Materials and Methods: In this experimental study, 24 male Wistar rats (weight 300-250 g) were selected and randomly assigned into three groups: baseline control, eight-week control and HIIT training. The experimental group performed training protocol 4 days a week during 8 weeks, while the control group had no training program. To measure the levels of serum irisin, nesfatin, and resistin, the immunoassay method was used. Additionally, the real-time PCR method was applied to evaluate the relative PGC-1α mRNA level in soleus muscle. Independent T-test was used to analyze the data. Results: The results suggested that there was no significant difference between the concentration of nesfatin, irisin and resistin in the baseline control group compared to the eight-week control group (P > 0.05). HIIT increased the concentrations of nesfatin-1 and irisin (P = 0.0001), and significantly decreased resistin (P = 0.0001). Furthermore, eight weeks of HIIT significantly increased the PGC-1α mRNA (P = 0.0001). Conclusion: According to the findings of the study, HIIT would possibly help to improve the levels of the factors, nesfatin, irisin, resistin and PGC-1α which involved in the energy balance homoeostasis.
کلیدواژه‌های انگلیسی مقاله High-intensity interval training, Nesfatin, Irisin, Resistin, PGC-1α, Rats
نویسندگان مقاله | Mozhgan Ahmadi
Department of Physical Education and Sport Science Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-444-1&slc_lang=en&sid=1
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/358/article-358-2473744.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Physical medicine
نوع مقاله منتشر شده پژوهشی
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