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Physiology and Pharmacology، جلد ۲۵، شماره ۲، صفحات ۱۶۲-۱۷۰
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عنوان انگلیسی Combination effects of gallic acid and cyclosporine A during ischemia/ reperfusion on rat electrocardiogram parameters and arrhythmia
چکیده انگلیسی مقاله Introduction: Myocardial ischemia leads to electrical disturbance in the heart because of reactive oxygen specious. This study aimed to investigate the effects of gallic acid and cyclosporine A (CsA) together on electrocardiogram parameters in myocardium following ischemia - reperfusion (I/R) in isolated hearts. Methods: In this research, 50 Wistar rats weighing 250-300g were randomly divided into the 5 following groups: control, sham and gallic acid (7.5, 15 and 30mg/kg) in combination with CsA (0.2μM). On the eleventh day, the hearts were removed and perfused with Krebs solution and ischemia was induced for 30min. Then, cyclosporine was administered for 10min at the 10 minutes before reperfusion and 10 minutes the beginning of reperfusion. By placing the electrode, the parameters of RR, PR, QT, TpeakTend, JT and QTcB interval, ST elevation, R, P, Q, S, T amplitude were recorded before ischemia and during reperfusion. Results: This study showed that RR, JT, interval, p duration, ST elevation and PVC numbers of control were increased during ischemia compared with sham and decreased using gallic acid (7.5, 15 and 30mg/kg) in combination with CsA. In addition, P, R, S, T amplitude during the ischemia were decreased in control compared with sham and increased with gallic acid (15mg/kg) in combination with CsA. Conclusion: In conclusion, the optimal combination of both drugs decreased arrhythmia occurrence while increased electrical velocity of conduction and wave amplitudes in isolated myocardium after ischemia reperfusion injury.
کلیدواژه‌های انگلیسی مقاله Gallic acid, Cyclosporine A, Ischemia reperfusion injury.
نویسندگان مقاله | Najmeh Sadeghi
Sirjan School of Medical Sciences , Sirjan, Iran


| Samira Saadatfard
Research Center for non. Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran


| Mahin Dianat
Department of Physiology, Faculty of Medicine, Ahvaz University of Medical Sciences, Ahvaz Iran


| Hassanali Abedi
Department of Physiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran


| Khatereh Dehghani
Department of Cardiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1324-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardiovascular Physiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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