| چکیده انگلیسی مقاله |
Introduction: The present study investigated the hepatoprotective effects of stigmas, tepals and leaves of Crocus sativus on carbon tetrachloride (CCL4) induced liver injury in rats. Methods: Hydroethanolic extracts of Crocus sativus (stigmas, tepals and leaves) were administrated daily for 14 days by oral gavage. In the present study, 30 male rats divided into five groups were treated as 1: normal rats gavaged with distilled water; 2: intoxicated rats gavaged with distilled water and injected with CCL4; 3: rats treated with stigmas extract and injected with CCL4; 4: rats treated with tepal extract and injected with CCL4; 5: rats treated with leaf extract and injected with CCL4. Bodyweight and the relative liver weight were determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total cholesterol, triglycerides, bilirubin direct and total, total protein, albumin, urea and creatinine measured in plasma. Malondialdehyde (MDA) was quantified in liver homogenate. Results: The experimental data showed that the stigmas and tepals extracts significantly prevented weight body loss and improved the relative liver weight. They significantly protected against elevation of ALT, AST, direct bilirubin, total bilirubin, LDH, ALP, creatinine and MDA. Also, they enhanced significantly total proteins and albumin compared to the CCL4 control group. Moreover, leaves reduced ALT, AST, total bilirubin, LDH and MDA significantly. Conclusion: In conclusion, these results suggest that tepals, stigmas, and leaves extracts of Crocus sativus have hepatoprotective effects on CCL4 induced liver injury in rats. |
| نویسندگان مقاله |
| Sabir Ouahhoud
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Ilham Touiss
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Amine Khoulati
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Iliass Lahmass
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Samira Mamri
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Mouhssine Meziane
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Soufiane Elassri
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Noureddine Bencheikh
Laboratory of Physiology, Genetics, and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Redouane Benabbas
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Abdeslam Asehraou
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
| Mohammed Choukri
Laboratory of Biochemistry, Central Laboratory Service - CHU, Mohammed VI, Faculty of Medicine and Pharmacy, University Mohamed Premier, Oujda, Morocco
| Ennouamane Saalaoui
Laboratory of Biochemistry and Biotechnology, Department of Biology, Faculty of Sciences, University Mohamed Premier, Oujda, Morocco
|