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Physiology and Pharmacology، جلد ۲۵، شماره ۱، صفحات ۲۱-۳۵
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عنوان انگلیسی Protective effect of honey on learning and memory impairment, depression and neurodegeneration induced by chronic unpredictable mild stress
چکیده انگلیسی مقاله Introduction: Chronic stress, which has been prevalent in human life, induce structural changes in the hippocampus. Depression and impairment of memory are serious comorbidities of chronic stress. In this study, we evaluated the impact of an Iranian honey pretreatment on memory deficit, depression and the hippocampal neuronal loss in the chronic unpredictable mild stress (CUMS) model. Methods: Adult male Wistar rats were divided into the control groups that received water or honey (0.2 or 2g/kg) and CUMS groups that subjected different, randomly and unpredictable mild stressors for 4 weeks. Ten days before starting the CUMS procedures, the animals received honey (0.2 or 2g/kg, daily, orally), which was continued until sacrificing. Morris water maze and sucrose performance tests were used to evaluate the spatial learning and memory and depressive-like behavior in the animals respectively. Hippocampus and whole brain samples were collected for further biochemical and histological analysis. Results: Honey reversed the depression-like behavior and ameliorated the spatial memory deficit induced by CUMS. Also, honey decreased cell death in the hippocampus and reduced the malondialdehyde level in treated animals. Conclusion: These results revealed that honey diminished learning and memory deficits and depression in chronic stress conditions.
کلیدواژه‌های انگلیسی مقاله Honey, Chronic mild stress, Learning and memory, Neuronal loss, Oxidative stress.
نویسندگان مقاله | Asiye Rafiee Sardooi
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Parham Reisi
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Azadeh Yazdi
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1080-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Learning and Memory
نوع مقاله منتشر شده Experimental research article
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