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Physiology and Pharmacology، جلد ۲۴، شماره ۴، صفحات ۲۸۵-۲۹۷
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عنوان انگلیسی Ginkgo biloba modulates hippocampal BDNF expression in a rat model of chronic restraint stress-induced depression
چکیده انگلیسی مقاله Introduction: Mood disorders such as depression and anxiety disorders have been affecting a relatively high proportion of the world's population. Neuroplasticity hypothesis of depression proposes that lack of brain-derived neurotrophic factor (BDNF) can cause structural changes in the brain. The extract of Ginkgo biloba (Gb) leaves can restore much of the damage in the nervous system. We examined the antidepressant role of Gb extract (EGb 761) on BDNF expression modulation in the hippocampus of rats subjected to repeated restraint stress (RRS). Methods: Adult male rats were randomly divided into 10 groups: control, control-vehicle treated, stress, stress-vehicle treated, as well as three control and three experimental groups pretreated with EGb (15, 30, 60mg/kg, IP daily) for 21 days. They underwent restraint stress on a daily basis, 6 hours for 21 consecutive days. Weight changes, locomotor activity and forced swim test (FST) were employed to assess depressive-like symptoms. The serum corticosterone level was also measured by ELISA. Hippocampal BDNF DNA methylation and protein expression were assayed by methylation sensitive restriction enzymes (Real Time PCR) and Western-blotting respectively in all groups. Results: Pre-treatment with 30 and 60 mg/kg/day of Gb extract significantly attenuated depressive-like effects in the body weight, FST and serum corticosterone level in RSS rats compared to control groups. Further, it inhibited chronic stress-induced alterations in the hippocampal BDNF DNA methylation and protein expression. Conclusion: These findings suggest that Gb can induce an antidepressant role through its modulation effect on the hippocampal BDNF expression.
کلیدواژه‌های انگلیسی مقاله Repeated restraint stress, Ginkgo biloba, Depression, DNA Methylation, BDNF expression.
نویسندگان مقاله | Seyed Abdolmajid Ayatollahi
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| shahrokh khoshsirat
Hearing Disorders Research Center, Loghman HakimMedical Center, Shahid Beheshti University ofMedical Sciences, Tehran, Iran


| Ali Asghar Peyvandi
Hearing Disorders Research Center, Loghman HakimMedical Center, Shahid Beheshti University ofMedical Sciences, Tehran, Iran


| Omidvar Rezaei
Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Fatemeh Zare Mehrjardi
Neurobiomedical Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran


| Arezo Nahavandi
Neuroscience Research Center, Department of Physiology, Iran University of Medical Sciences, Tehran, Iran


| Somayeh Niknazar
Hearing Disorders Research Center, Loghman HakimMedical Center, Shahid Beheshti University ofMedical Sciences, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1299-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacokinetics/Dynamics
نوع مقاله منتشر شده Experimental research article
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