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Physiology and Pharmacology، جلد ۲۴، شماره ۳، صفحات ۱۹۷-۲۰۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of minocycline on lumbar radicular pain: a prospective pilot study
چکیده انگلیسی مقاله Introduction: Pain is an unpleasant sensory and emotional experience. Evidence suggests a role for microglia in chronic pain and inhibition of microglia leads to decrease of chronic pain intensity in animal models. Minocycline, a semisynthetic tetracycline derivative, is a selective inhibitor of microglia. Several studies have shown pain intensity improvement by minocycline in animal model of pain, but a few studies showed effectiveness on chronic pain improvement in humans. This prospective, self-controlled clinical trial investigated whether minocycline is effective for chronic pain management. Methods: Twenty-two patients, between the ages of 20 and 80 years with radicular lumbar pain with a numerical rating scale >4, who were unresponsive to other medications and had pain duration of >6 weeks were included in the trial. Results: Pain intensity, neuropathic pain and life quality scores assessed before and after treatment. All scores showed significant improvement after 2 weeks of treatment: 56%, 74% and 14%, respectively. Conclusion: Findings of this study suggest minocycline can effectively improve patients' pain scores and quality of life, even in those with long-term duration of chronic pain and warrants further study.
کلیدواژه‌های انگلیسی مقاله Minocycline, Low back radicular pain, Chronic pain.
نویسندگان مقاله | Sanaz Sha'abani
Department of Anesthesiology, Saveh University of Medical Sciences, Saveh, Iran


| Sasan Gazerani
Department of Physiology, Saveh University of Medical Sciences, Saveh,, Iran


| Maryam Ragheb
Nursery School, Saveh University of Medical Sciences, Saveh, Iran


| Amir-Hossein Mirgalou-Bayat
Department of Anesthesiology, Saveh University of Medical Sciences, Saveh, Iran


| Mark Kennet Huntington
The Center for Family Medicine, University of South Dakota, Sanford School of Medicine, Sioux Falls, South Dakota, USA
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-1320-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Experimental research article
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