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International Journal of Radiation Research، جلد ۱۹، شماره ۴، صفحات ۸۷۹-۸۸۹
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Efficiency of modulated and dose rate altered flattening filter free beams in high dose per fraction radiotherapy applications on the survival of prostate cancer cell lines
چکیده انگلیسی مقاله Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose.
کلیدواژه‌های انگلیسی مقاله Flattening filter free, Cell survival, Radiosurgery, Radiobiology
نویسندگان مقاله | C. Ceylan
Center for Stem Cell and Gene Therapies Research and Practice, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey


| A. Öztürk
Center for Stem Cell and Gene Therapies Research and Practice, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey


| G. Güngör
Department of Radiation Oncology, Acibadem University, Istanbul, Turkey


| A.U. Karabey
Department of Radiation Oncology, Kocaeli University, Kocaeli, Turkey


| S. Şahin
Vocational School of Health Services, Fenerbahce University, Istanbul, Turkey


| G. Duruksu
Center for Stem Cell and Gene Therapies Research and Practice, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey


| Y. Yazır
Center for Stem Cell and Gene Therapies Research and Practice, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey


| G. Aksu
Department of Radiation Oncology, Kocaeli University, Kocaeli, Turkey


| Ö. Gündoğdu
Deparment of Biomedical Engineering, Kocaeli Univetsity, Kocaeli, Turkey
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-878&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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