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International Journal of Radiation Research، جلد ۱۸، شماره ۴، صفحات ۷۷۷-۷۸۴
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چکیده فارسی مقاله
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عنوان انگلیسی Intraoperative radiotherapy (IORT) induced key molecular pathways in tumor bed of breast cancer patients: a pilot study
چکیده انگلیسی مقاله Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function of IORT. Materials and Methods: Six Breast Cancer (BC) patients as a pilot study were treated by 12 Gy (Boost dose) and 21 Gy (Radical dose). Samples tissue included Margin before IORT (MB), and Margin 24 hours After IORT (MA24 h). High-throughput technology such as Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) was performed to study proteomic of IORT-treated tumor bed. Results: We classified 110 differentially expressed proteins (DEPs) as a protein biomarker panel by mapping the annotated coding region sequences to the reference canonical pathways in the KEGG database. Conclusion: The analyses of protein function and signaling pathways of these DEPs reveal a molecular response to the effectiveness of IORT.
کلیدواژه‌های انگلیسی مقاله Intraoperative radiation therapy (IORT), proteomic.
نویسندگان مقاله | M. Shahani
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| J. Shakeri
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| M.E. Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| A. Tafti
Department of Medical Biotechnology, Faculty of Medicine, Arak University of Medical Science, Arak, Iran


| H. Zali
School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| N. Nafisi
Breast Department, Iran University of Medical Sciences, Tehran, Iran


| M. Rezaei-Tavirani
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| S.H. Jamaldini Ezabady
Department of Genetics, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran


| A. Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| M. Samsami
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-2055-63&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Medical Physics
نوع مقاله منتشر شده تحقیق بدیع
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