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International Journal of Radiation Research، جلد ۱۸، شماره ۴، صفحات ۸۰۹-۸۱۵
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عنوان انگلیسی Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit
چکیده انگلیسی مقاله Background: The total yields of direct Single-Strand Breaks (SSBs) and Double-Strand Breaks (DSBs) in proton energies varying from 0.1 to 40 MeV were calculated. While other studies in this field have not used protons with energy less than 0.5 MeV, our results show interesting and complicated behavior of these protons. Materials and Methods: The simulation has been done using the Geant4-DNA toolkit. An atomic model of DNA geometry was simulated. Simulations were performed with a source in the Z-axis direction at the cell nucleus entrance with protons at energies of 0.1-1 MeV in 0.1 MeV steps, 5 MeV, and 10-40 MeV in 10 MeV steps. Results: The calculated SSB yields decreased from 60.08 (GbpGy)−1 for 0.1 MeV proton energy to 49.52 (GbpGy)−1 for 0.5 MeV proton energy, and then it increased to 54.35 (GbpGy)−1 in 40 MeV. The DSB yields decreased from 4.32 (GbpGy)−1 for 0.1 MeV proton energy to 1.03 (GbpGy)−1 for 40-MeV protons. The DSB yields for energies less than 0.5 MeV was about 56%, and for the other energy levels, it was 44%. As for SSB yields, 35% of the breaks arose from protons with an energy of fewer than 0.5 MeV and 65% from higher energies. Conclusion: It was found that the proton ranges with an energy less than 0.5 MeV are smaller than the cell size (10 μm), and 100% of the energy is deposited in the cell region. Then protons with these energies are the best choice to increase the number of DSBs.
کلیدواژه‌های انگلیسی مقاله Monte Carlo simulation, proton, SSB yield, DSB yield.
نویسندگان مقاله | Z. Ahmadi Ganjeh
Department of Physics, School of Science, Yazd University, Yazd, Iran


| M. Eslami-Kalantari
Department of Physics, School of Science, Yazd University, Yazd, Iran


| M. Ebrahimi Loushab
Department of Physics, Faculty of Montazeri, Technical and Vocational University (TVU), Khorasan Razavi, Iran


| A.A. Mowlavi
Department of Physics, Hakim Sabzevari University, Sabzevar, Iran
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-2055-67&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Medical Physics
نوع مقاله منتشر شده تحقیق بدیع
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