| چکیده انگلیسی مقاله |
Several months have passed since the onset of the COVID-19 pandemic. Multiple characteristics have been proposed as prognostic factors so far. This study aims to provide evidence on the association of neutrophil-to-lymphocyte ratio (NLR) at the hospitalization time and three desired outcomes (mortality, prolonged hospitalization, and intensive care unit [ICU] admission). We designed a single-centre retrospective observational study in Baharloo Hospital (Tehran, Iran) from 20 February to 19 April 2020. Patients with confirmed COVID-19 diagnosis via rt-PCR or chest CT imaging were included. Demographic and clinical data were obtained. The sample was divided into three groups, using tertile boundaries of initial NLR. The differences in mortality, comorbidities, hospitalization duration, drug administration, and ICU admission between these three groups were investigated. The identified confounding factors were adjusted to calculate the odds ratio of death, ICU admission, and prolonged hospitalization. Nine hundred sixty-three patients were included. In total, 151 and 212 participants experienced mortality and ICU admission, respectively. In multivariate logistic regression models, the adjusted odds ratio for mortality event in the second and third tertile of initial NLR after full adjustment were 1.89 (95% CI:1.07-3.32) and 2.57 (95% CI:1.48-4.43) and for ICU admission were 1.85 (95% CI:1.14-3.01) and 2.88 (95% CI:1.79-4.61), respectively. The optimal cut-off value of the initial NLR for predicting mortality was 4.27. Initial NLR can predict mortality and ICU admission in COVID-19 patients. Further investigations for curating the calculated cut-off can propose initial NLR as an indicator of poor prognosis for COVID-19 patients. |
| نویسندگان مقاله |
| Zahedin Kheyri
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
| Sepehr Metanat
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.AND Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
| Hadiseh Hosamirudsari
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Samaneh Akbarpour
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Shojaei
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
| Neda Faraji
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Fariba Mansouri
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
| Fatemeh Taghizadeh
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Fatemeh Ahmadian
Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
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