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Acta Medica Iranica، جلد ۵۹، شماره ۹، صفحات ۵۱۶-۵۲۳
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عنوان انگلیسی Study on the Critical Roles of Apoptosis in Asthma Disease
چکیده انگلیسی مقاله Inflammation, and remodeling in airways are the two crucial characteristics of asthma, a common respiratory disease. In asthma pathophysiology, the recruitment of granulocytes finally results in inflammation, leading to lung damage. In this regard, failure to clear inflammatory cells by programmed cell death, apoptosis will cause the prolongation of inflammation. On the other hand, in airway epithelial cells, apoptosis may occur, resulting in airway remodeling. Hence, dysregulation of apoptosis has been suggested to contribute to the development of asthma. Importantly, knowledge of the factors related to apoptotic cascade seems vital to explore various pharmacological interventions for the treatment of asthma. In this review, we highlight several important apoptotic and anti-apoptotic factors contributing either to inflammatory cells or airway epithelial cells involved in asthma pathogenesis.
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نویسندگان مقاله | Farzaneh Kianian
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mehri Kadkhodaee
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Hamid Reza Sadeghipour
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Behjat Seifi
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8889
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