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Acta Medica Iranica، جلد ۵۹، شماره ۳، صفحات ۱۴۲-۱۴۷
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عنوان انگلیسی The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients
چکیده انگلیسی مقاله Adiponectin is an adipocytokine that has a higher serum level in healthy people. In type 2 diabetes, insulin resistance, hypertension, MI, and dyslipidemia, the serum level of adiponectin is lower than 4 µg/mL. Adiponectin is proved to have a protective role against atherosclerotic changes where its low serum levels in type 2 diabetes can lead to the progression of atherosclerotic lesions. In this study, we aimed to survey the possible effects of adiponectin in the development of coronary artery disease in type 2 diabetics. Thirty diabetic cases with coronary artery disease, 30 diabetic cases without known coronary artery disease, and a group of 30 healthy volunteers, all of them were between 18-65-year-old, were entered our study. We gathered demographic data by performing a physical examination followed by filling a checklist and a set of laboratory tests. All the groups were sex and age-matched (P=0.284 and P=0.163 respectively). CAD group had the lowest HBA1C (P< 0.001). Both LDL and HDL were also lower in the CAD group (P< 0.001). Adiponectin was also lower in the CAD group when compared to other groups (P< 0.008) or when compared with only normal diabetics (P< 0.002). We found a correlation between adiponectin and HDL (r=0.348, P=0.008), suggesting each unit of reduction in serum level of adiponectin could increase the chance of coronary artery disease by 38% in diabetics. In this study, we showed that the lower serum level of adiponectin is correlated with an increased risk of coronary artery disease in type 2 diabetics.
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نویسندگان مقاله | Zahra Mazloum Khorasani
Metabolic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Saeed Choobkar
Mashhad University of Medical Sciences, Mashhad, Iran


| Ramin Khameneh Bagheri
Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mina AkbariRad
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Abdollah Firoozi
Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8626
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