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Acta Medica Iranica، جلد ۵۸، شماره ۱۱، صفحات ۵۴۴-۵۵۱
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عنوان انگلیسی Regulatory Functions of MicroRNAs in Cancer Pathogenesis
چکیده انگلیسی مقاله MicroRNAs (miRNAs) are a large family of evolutionary conserved small non-coding RNA molecules that firstly discovered in 1993. They regulate gene expression of about 50% of protein-coding genes at the post-transcriptional level. MiRNAs can target numerous messenger RNAs and subsequent misexpression of them can affect many different signaling pathways. They are playing a pivotal role in cancer development by regulation of the genes expression which involved in the proliferation, survival, differentiation, apoptosis or metastasis of the cancer cells. Several treatment approaches such as inhibition of oncomiRs and restoration of tumor suppressor miRNAs have been established in certain types of cancers and some other miRNA-based strategies are in development for cancer prevention and treatment. Nowadays, cancer is the most important target of miRNA therapeutics and the specific mechanisms by which miRNA mediates cancer pathways needs more research and study.
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نویسندگان مقاله | Mahafarin Maralani
Department of Medical Oncology, MOCA, University Hospital Antwerp (UZA), Antwerp, Belgium. AND Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.


| Behzad Baradaran
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Khalil Hajiasgharzadeh
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AND Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


| Marc Peeters
Department of Medical Oncology, MOCA, University Hospital Antwerp (UZA), Antwerp, Belgium
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8300
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