این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Acta Medica Iranica، جلد ۵۸، شماره ۹، صفحات ۴۶۱-۴۶۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Oct4 Is Not a Crucial Factor in Breast Invasive Ductal Carcinoma in Contrast to Recent Beliefs
چکیده انگلیسی مقاله We aimed to determine the frequency of Octamer binding transcription factor 4 (Oct4) expression in human invasive ductal carcinoma. 72 paraffin-embedded samples of breast cancer were enrolled. All blocks were stained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2(HER 2/neu), ki67, and Oct4 by immunohistochemistry (IHC) method. Of 72 enrolled cases, the mean age was 49.6±1.42 years. 18 (25%) of cases were luminal A, 14 (19.4%) were Her2 positive, 31 (43%) were luminal B, and 9 (12.5%) were triple-negative. IHC staining for Oct4 revealed no Oct4 expression in breast cancer samples. The staining was repeated twice, and seminoma was used as a positive control in each run. The results of both repeats were the same, and none of the examined samples showed Oct4 expression. We found no Oct4 expression in breast cancer samples examined in our study. We also did not find Oct4 expression in normal breast tissue. Our study is one of the few studies which has evaluated Oct4 expression in human breast cancer on tissue samples and is one of the least that has reported no expression of Oct4 in breast cancer.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Ata Abbasi
Department of Pathology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Farahnaz Noroozinia
Department of Pathology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Sonia Hosseinzadeh
Department of Pathology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.


| Mohammad Amin Abbasi
Firoozabadi Hospital Clinical Research Development Unit (FHCRDU), Iran University of Medical Sciences, Tehran, Iran


| Samira Anvar
Department of Pathology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Seyed Arman Seyed Mokhtari
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8357
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات