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Acta Medica Iranica، جلد ۵۸، شماره ۳، صفحات ۱۲۱-۱۲۵
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عنوان انگلیسی The Effect of Preoperative Administration of Duloxetine on Postoperative Pain After Laparoscopic Myomectomy
چکیده انگلیسی مقاله The purpose of this study was to evaluate the effect of preoperative administration of duloxetine on postoperative pain after laparoscopic myomectomy. In this double-blind clinical trial study, 57 patients aged 18-55 years with ASA I or II undergoing laparoscopic myomectomy involved. The case group received oral duloxetine 60 mg, and the control group received placebo 2 hours before the surgery. Pain scores, total analgesic consumption during 24 hours, recovery discharging time, nausea, vomiting, dizziness, and hemodynamic changes were recorded and compared between two groups. The pain severity was significantly lower in the case group at 2, 12, and 24 hours after the operation (P< 0.05). There were no significant differences in dizziness, nausea, vomiting, systolic and diastolic blood pressure, and heart rate of patients between two groups before the surgery, 5 and 30 minutes after the induction, and after the recovery. Duloxetine administration prior to laparoscopic surgery myomectomy can reduce postoperative pain without inducing side effects in patients.
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نویسندگان مقاله | Maryam Hatami
Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Arezoo Kheirati
Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Shekoufeh Behdad
Departments of Anesthesiology, Pain Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Atiye Javaheri
Departments of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Sedighe Vaziribozorg
Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8161
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