| چکیده انگلیسی مقاله |
Background: Tracheoesophageal voice prostheses (TVPs) have been the gold standard in rehabilitation, after laryngectomy, producing faster and premier voicing towards esophageal speech. Fungal colonization shortens the device’s lifetime and leads to prosthesis dysfunction, leakage, and subsequent respiratory infection. Therefore, in the current study, we aimed to investigate the fungal colonization patterns and to propose prophylactic measures that shall increase the longevity of voice prosthesis.
Methods: Failed TVPs were removed - due to leakage and/or aspiration - from 66 post laryngectomy patients and examined. They were referred to Amiralam and Rasoul Hospital, the main centers of Ear, Nose, and Throat in Tehran, Iran from April 2018 to January 2020. Fungal colonization patterns were assessed using DNA sequencing techniques. Furthermore, the susceptibility to fluconazole, amphotericin B, nystatin, and white vinegar was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines.
Results: Resident fungal species from the upper airways colonized all the 66 TVPs (100%). Diabetes (31%) and smoking (98%) were the predominant underlying disease and predisposing factors, respectively. Among the 79 fungal agents isolated from the 66 TVPs, Candida glabrata (n=25, 31.7%) was the most common. A significant reduction in minimum inhibitory concentration (MIC) values were observed for white vinegar when used alone (P< 0.05).
Conclusion: White vinegar at a very low concentration could decrease the amount of fungal colonization on TVPs without any adverse effects; its wide accessibility and affordability ensure a decrease in the overall health cost. |
| نویسندگان مقاله |
| Hasti Kamali sarvestani
Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Roshanak Daie Ghazvini
Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Syed Jamal Hashemi
1. Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Mohsen Geramishoar
Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Saham Ansari
Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Zahra Rafat
Department of Medical Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Aslan Ahmadi
Head and Neck Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
| Pedram Borghei
Department of Head and Neck Surgery, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Miad Elahi
Department of Head and Neck Surgery, Amir A’lam Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Abas Rahmi foroushani
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Muhammad Ibrahim Getso
1. Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University Kano, PMB 3011, Kano, Nigeria
| Shima Aboutalebian
Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
| Fatemeh Safari
Department of Microbiology, Islamic Azad University, Falavarjan Branch, Isfahan, Iran
| Pegah Ardi
Department of Medical Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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