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Iranian Journal of Public Health، جلد ۵۱، شماره ۱، صفحات ۱۷۲-۱۷۷
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عنوان انگلیسی Liver Biomarkers Assay in COVID-19 Cases: A Comparison Study between Alive and Dead Patients
چکیده انگلیسی مقاله Background: Identifying effective biomarkers plays a critical role on screening; rapid diagnosis; proper managements and therapeutic options, which is helpful in preventing serious complications. The present study aimed to compare the liver laboratory tests between alive and dead hospitalized cases for prediction and proper management of the patients. Methods: This retrospective, cross sectional study consists of all deceased patients admitted in one center in Shiraz, Iran during 19 Feb 2020 to 22 Aug 2021. For further comparison, we selected a 1:2 ratios alive group randomly. Results: Overall, 875 hospitalized cases died due to COVID-19. We selected 1750 alive group randomly. The median age was significantly higher in died group (65.96 vs 51.20). Regarding the laboratory findings during the hospitalization ALT, AST, Bili.D were significantly higher in non-survivors than survivors but Albumin was less in deceased patients. It was revealed elevated levels of Albumin, AST, Bili.T and Bili.D were associated with increasing the risk of in hospital death. Moreover, the predictive effect of ALP and Bili.D had significantly more than others with high sensitivity and specify. Conclusion: We found patients with COVID-19 have reduced serum albumin level, and increase ALT and AST. The current results revealed abnormal liver chemistries is associated with poor outcome, which highlighted the importance of monitoring these patients more carefully and should be given more caution.
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نویسندگان مقاله | Amir Emami
Department of Microbiology, Burn & Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Fatemeh Javanmardi
Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Ali Akbari
Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Babak Shirazi Yeganeh
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Tahereh Rezaei
Department of Microbiology, Burn & Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Hamid Bakhtiari
Vice Chancellor for Health Affairs Center of Disease Control (CDC), Shiraz University of Medical Sciences, Shiraz, Iran


| Neda Pirboneyh
Department of Microbiology, Burn & Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/26119
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