این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۰، شماره ۹، صفحات ۱۸۲۵-۱۸۳۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Copper-Containing Stainless Steel on Apoptosis of Coronary Artery Smooth Muscle Cells
چکیده انگلیسی مقاله Background: We aimed to investigate the effect of copper stainless steel on apoptosis of vascular smooth muscle cells in coronary artery. Methods: The study was carried out in 2019 at Hubei University of Medicine, Xiangyang, China. The rat coronary artery smooth muscle cell was used for cell resuscitation and culture. MTT method was used to visualize cell growth curve and to detect the cell survival and growth. The incubated cells were randomly divided into copper-containing stainless-steel group, ordinary stainless-steel group, and control group. The cells were made into single cell suspension, which were intervened by experimental group and incubated in incubator with CO2 for 48 hours. TUNEL method was used to detect the apoptosis. The number of apoptotic cells in five high power fields (×200) was counted. The expression of Fas protein in three groups of cells was detected by Western blot. Results: The growth curves of rat coronary artery smooth muscle cells showed that the OD value of the cells reached the plateau 7 days after inoculation, indicating that the cells grew well. TUNEL staining showed the apoptosis in all three groups. The apoptotic index in copper-containing group was significantly higher than that in common stainless-steel group (P < 0.01). The results of the Fas protein expression level through Western blot showed that the level in the copper-containing group was significantly higher than that in the common stainless-steel group (P< 0.01). Conclusion: Copper-containing stainless steel can promote apoptosis of coronary artery smooth muscle cells. The material could prevent stent restenosis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Hui Li
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China


| Xiaolan Li
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China


| Tingjia Cao
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China


| Qiang Zhu
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China


| Fuyuan Liu
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China


| Heng Zhou
Department of Cardiovascular Medicine, Xiangyang No.1 People&apos;s Hospital, Hubei University of Medi-cine, Xiangyang 441000, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/23725
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات