این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۰، شماره ۹، صفحات ۱۸۸۲-۱۸۸۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Frequency of HLA Alleles in a Group of Severe COVID‐19 Iranian Patients
چکیده انگلیسی مقاله Background: Human Leukocyte Antigen (HLA) system composed of a group of related proteins with important functions in the immune system. Several studies have reported that there is a significant association between specific HLA alleles and the susceptibility to different infectious diseases. This study aimed to detect the specific HLA alleles that cause higher susceptibility to COVID-19, we analyzed the HLA allele frequency distribution in Iranian patients with a severe form of COVID-19. Methods: Overall, 48 severe cases of COVID-19 that were hospitalized and required intensive care unit (ICU) admission between Oct and Dec 2020 were included in this study. Genomic DNA was extracted from the peripheral blood samples and HLA typing (Locus A, B, and DR) was performed for the patients. Results: After analyzing and comparing the results with a reference group of 500 Iranian individuals, a significant association was found for HLA-B*38, HLA-A*68, HLA-A*24, and HLA-DRB1*01. Conclusion: These results may be valuable for studying the potential association of specific HLA alleles with susceptibility to COVID-19 and mortality due to the disease.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Ramin Hamidi Farahani
Department of Infectious Diseases, School of Medicine, AJA University of Medical Sciences, Tehran, Iran


| Emran Esmaeilzadeh
1. Department of Basic Medical Sciences, School of Medicine, AJA University of Medical Sciences, Tehran, Iran 2. Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran


| Amir Nezami Asl
Department of Aerospace Medicine, School of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran


| Mohammad Foad Heidari
Department of Laboratory Sciences, School of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran


| Ebrahim Hazrati
Department of Critical Care Medicine, School of Allied Medical Sciences, AJA University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/23866
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات