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Iranian Journal of Public Health، جلد ۵۰، شماره ۸، صفحات ۱۵۱۷-۱۵۲۵
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عنوان انگلیسی Association between Thyroid Disease and Severe Coronavirus Disease 2019 (COVID-19) Infection: A Meta-Analysis
چکیده انگلیسی مقاله Background: COVID-19 has resulted in an emerging respiratory infection with a pandemical diffusion since December 2019. We aimed to elucidate whether the presence of thyroid disease might increase the risk of severe COVID-19 infection. Methods: Studies reporting seriously ill in COVID-19 patients with and without thyroid disease combined were searched and 11 relevant studies were subjected to our analysis, and pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated by using STATA and Review Manager Software. Results: In total, 2,995 COVID-19 patients were included in this study. The pooled ORs were calculated using a fixed-effects model according to the heterogeneity. The pooled results revealed that thyroid disease was associated with severe COVID-19 infection in patients (OR = 2.14, 95 % CI: 1.23–3.72, P = 0.007). In the subgroup analysis by type of thyroid disease, hypothyroidism was positively associated with risks of severe COVID-19 infection (OR = 4.78, 95 % CI: 1.59–14.36, P = 0.005), however, no obvious difference was found in the risk regarding the severe COVID-19 infection amongst hyperthyroidism or unclassified thyroid disease. In addition, subgroup analysis stratified by ethnic groups demonstrated that thyroid disease was linked to the risks of severe COVID-19 infection in Asian patients (OR = 2.41, 95 % CI: 1.30–4.48, P = 0.005) rather than non-Asian (OR = 1.31, 95 % CI: 0.35–4.87, P = 0.684). Conclusion: This study indicates a correlation between thyroid disease and severe COVID-19 infection.
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نویسندگان مقاله | Juan Xu
Department of Internal Medicine, The People’s Hospital of Guandu District, 63 Yingfeng Road, Kunming 650200, China


| Yang Li
Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China


| Quansong Xia
Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China


| Qiong Shi
Department of Clinical Laboratory, The Third Affiliated Hospital of Kunming Medical University, 519 Kunzhou Road, Kun-ming 650118, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/24594
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