این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۰، شماره ۸، صفحات ۱۶۹۷-۱۷۰۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
چکیده انگلیسی مقاله Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Fatemeh Esfahanian
Department of Endocrinology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


| Mojgan Mirabdolhagh Hazaveh
Department of Internal Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Laya Hooshmand Garehbagh
Department of Endocrinology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran


| Kowsar Falahati
Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran


| Mitra Ataei
Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran


| Mohammad Hossein Sanati
Clinical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran


| Zohreh Jadali
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/19484
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات