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Iranian Journal of Public Health، جلد ۴۹، شماره ۱۱، صفحات ۲۰۲۲-۲۰۳۱
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عنوان انگلیسی Convalescent Plasma in the Treatment of Severe COVID-19: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: COVID-19 is a public health emergency of international concern. Its incidence rates and mortality are very high; however, so far, an effective drug treatment remains unknown. Based on the role of convalescent plasma therapy in previously identified viral pneumonias, patients with severe COVID-19 have been given this therapy. This systematic review and meta-analysis aimed to summarize the clinical evidence regarding the efficacy and safety of convalescent plasma therapy in the treatment of severe COVID-19. Methods: PubMed, Embase, Ovid, China Knowledge Network, China Biomedical, VIP Chinese Sci-tech Journal, Wanfang Database, and the International Clinical Trials Registry Platform were searched up to 21 June 2020, to identify clinical studies and registered trials on the use of convalescent plasma in the treatment of critically ill patients with COVID-19. Stata 13.0 was used to perform Meta-analysis. All records were screened as per the protocol eligibility criteria. Results: Nineteen clinical reports regarding convalescent plasma in the treatment of severe COVID-19 were included. Through systematic analysis, convalescent plasma was found to yield some efficacy on severe COVID-19 and had almost no obvious adverse reactions. Conclusion: Convalescent plasma therapy seems to yield some efficacy among patients with severe COVID-19 and almost no obvious adverse reactions were found. However, at present, the clinical evidence is insufficient, and there is an urgent need for support from high-quality clinical trial data.
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نویسندگان مقاله | Xuanguo ZHANG
Intensive Care Unit, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, 710003, China


| Fang PANG
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400016, China


| Fang PANG
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400016, China


| Yan DU
Graduate School, Shaanxi University of Chinese Medicine, Xianyang, 712046, China


| Qiuzhen YUAN
Department of Pharmacy, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, 710003, China


| Minjuan SHI
Department of Pharmacy, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, 710003, China


| Jiping LIU
Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, 712046, China


| Hui MA
Department of Healthcare-Associated Infection Control, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, 710003, China


| Dariush D. FARHUD
School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Departments of Basic Sciences/Ethics, Iranian Academy of Medical Sciences, Tehran, Iran AND Farhud Genetic Clinic, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/21986
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