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Iranian Journal of Public Health، جلد ۴۹، شماره ۱۱، صفحات ۲۱۰۳-۲۱۱۰
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عنوان انگلیسی 11, 13-Dehydro Lactone Moiety in Gynecologic Cancer Cells
چکیده انگلیسی مقاله Background: To study the anti-cancer effect of isoalantolactone, a sesquiterpene    lactoneisolated from the roots of Inula heleniumon human gynecologic cancer cells. Methods: A structure-activity relationship experiment was designed to identify the functional moiety of isoalantolactone for its significant anti-cancer activity. Five gynecologic cancer cell lines were treated with isoalantolactone. Cell proliferation was determined by MTT assay in vitro and cell apoptosis by flow cytometry. Results: We found isoalantolactone strongly inhibited the cell proliferationofHEC-1, HAC-2, HOC-21, and HeLa cells. Its inhibitory effect was comparable to that of well-known chemotherapeutic agents, cisplatin and taxol. Furthermore, isoalantolactone induced apoptosis in HeLa cells via caspase. On the contrary, its 11, 13-dihydro derivatives had much weaker anti-proliferative activities than the parent compound. Conclusion: Isoalantolactone exhibited strong anti-proliferative activities and apoptosis-inducing effects on gynecologic cancer cells. The 11, 13-dehydro lactone moiety was critical for its anti-proliferative activity.
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نویسندگان مقاله | Yibing LIU
Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China


| Qingju MENG
Department of Orthopedics, The First Hospital of Xingtai, Xingtai, Hebei Province, China


| Li JING
Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China


| Li FENG
Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China


| Zhiguo ZHOU
Department of Medical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China


| Zhiyu NI
School of Basic Medical Science, Hebei University, The Affiliated Hospital of Hebei University, Bao ding, Hebei Province, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/21280
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