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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۲، صفحات ۱۷۹-۱۸۶
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عنوان انگلیسی Crocin ameliorates MicroRNAs-associated ER stress in type 2 diabetes induced by methylglyoxal
چکیده انگلیسی مقاله Objective(s): Methylglyoxal (MG) provokes endoplasmic reticulum (ER) stress in β-cells and triggers pancreatic β-cell dysfunction. Crocin has anti-diabetic properties. The present study investigated whether crocin prevented pancreas damages induced by MG.Materials and Methods: Diabetes was induced by MG administration (600 mg/kg/day, PO). On the fourteenth day, after proving hyperglycemia, crocin (15, 30, and 60 mg/kg) and metformin (MT) (150 mg/kg) were used for detoxification of MG until the end of the experiment. The animals were divided into 6 groups: 1) control, 2) diabetic by MG, 3) MG + crocin 15 mg/kg, 4) MG + crocin 30 mg/kg, 5) MG + crocin 60 mg/kg, and 6) MG + MT. The data were analyzed by one-way analysis of variance and significant differences were compared by Tukey and Bonferroni tests (P< 0.05). Biochemical assays, antioxidant evaluation, and microRNAs expression associated with ER stress were assessed.Results: MG induced hyperglycemia, insulin resistance, and dyslipidemia (P< 0.001). Crocin and MT significantly ameliorated β-cell function through reduction of fasting blood glucose, malondialdehyde levels (P< 0.001), and significant elevation of anti-oxidant enzyme activity accompanied by regulation of glutathione and glyoxalase1-Nrf2 in MG induced diabetic mice. Crocin and MT significantly down-regulated microRNAs 204, 216b, 192, and 29a expression (P< 0.001). Crocin (60 mg/kg) (P< 0.01) and MT (P< 0.001) could improve diameter of pancreatic islets in MG treated mice. Conclusion: Crocin prevents the progression of diabetes through modulating ER stress-associated microRNAs and GLO1 activity with the helpful effects of glutathione and Nrf2.
کلیدواژه‌های انگلیسی مقاله Crocin, Diabetes, ER stress, Glyoxalase 1, Methylglyoxal, miR-204
نویسندگان مقاله | Vahid Radmehr
Student Research Committee, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Akram Ahangarpour
Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Seyyed Ali Mard
Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran|Alimentary tract research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Layasadat Khorsandi
Department of Anatomical Sciences, School of Medicine, Medical Basic Sciences Research Institute, Cellular and molecular research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_19607.html
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