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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۲، صفحات ۲۴۵-۲۵۳
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عنوان انگلیسی Aerobic training improves blood-brain barrier and neuronal apoptosis in experimental autoimmune encephalomyelitis
چکیده انگلیسی مقاله Objective(s): Blood-brain barrier (BBB) permeability is central in multiple sclerosis (MS) pathophysiology, and exercise may improve BBB integrity. The current study investigated the prophylactic and/ or therapeutic role of aerobic exercise (EX) training on BBB integrity in experimental autoimmune encephalomyelitis (EAE). Materials and Methods: Forty female Lewis rats were randomly divided into four groups. The experimental groups included: no-EAE induction+ no-exercise (no-EAE+ no-EX), no-EAE induction+ exercise (no-EAE+EX), EAE induction+ no-exercise (EAE+ no-EX), and EAE induction+ exercise (EAE+EX). The no-EAE+EX and EAE+EX groups performed six weeks of progressive aerobic exercise training. GFAP, angiopoietin 1 (Ang-1) expression, tight-junction (TJ) proteins of claudin-5 and occludin were measured as components of BBB integrity and the rate of neuronal apoptosis was evaluated in hippocampi. Results: A significant increase in GFAP and Ang-1 expression (P< 0.001) and conversely a down-regulation in TJ proteins (P< 0.05) was found in the brains of the no-EAE+EX group compared with the no-EAE+ no-EX group. The expression of GFAP and Ang-1 proteins significantly increased in the hippocampi of the EAE+ no-EX group (P< 0.001), whereas aerobic training (in the EAE+EX group) meaningfully reversed such increases (P< 0.001). Besides, down-regulated TJ proteins and increased neuronal apoptosis induced by EAE induction (EAE+ no-EX group) were restored and reduced, respectively, by aerobic training in the CNS of the EAE+EX group (P< 0.001). Conclusion: The provision of a six-week treadmill aerobic training buffered the detrimental effects of EAE on BBB integrity and consequently neuronal apoptosis. 
کلیدواژه‌های انگلیسی مقاله Aerobic training, Astrogliosis, Brain barrier dysfunction, Claudin-5, EAE model, Occludin
نویسندگان مقاله | Omid Razi
Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran


| Abdolhossein Parnow
Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Razi University, Kermanshah, Iran


| Iraj Rashidi
Department of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Nafiseh Pakravan
Department of Immunology, School of Medicine, Alborz University of Medical Science, Karaj, Iran


| Seyed Ershad Nedaei
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Robert Motl
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, United States of America
نشانی اینترنتی https://ijbms.mums.ac.ir/article_19659.html
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نوع مقاله منتشر شده Original Article
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