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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۱، صفحات ۱۲۶-۱۳۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Biliary cirrhosis-induced cardiac abnormality in rats: Interaction between Farnesoid-X-activated receptors and the cardiac uncoupling proteins 2 and 3 |
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| چکیده انگلیسی مقاله |
Objective(s): This study aimed to evaluate the relationship between Farnesoid-X-activated receptors (FXR) as nuclear regulators of the antioxidant defense system as well as cardiac mitochondrial carrier proteins of UCP2 and UCP3 in cardiac damage induced by cirrhosis. Materials and Methods: Twenty-two male Wistar rats (200–250 g) were randomly divided into 3 experimental groups, including a control group (n=6), a sham-operated group (n=8), and a bile duct ligated (BDL) group (n=8). Four weeks after surgical intervention, biochemical assessment (AST, ALT, GGT, LDH, and ALP), histological observation, and molecular evaluation (FXR, UCP2, UCP3, BNP, Caspase3, and GAPDH) using real-time RT-PCR were performed. Results: Compared with the sham-operation group, the BDL group showed a significant rise in liver enzymes of AST, ALT, GGT, LDH, and ALP. Defined fibrotic and necrotic bundles and thick reticulin fibers were also found in BDL liver tissue. Besides liver morphological alterations, left ventricles of BDL ones were also associated with defined cardiomyocyte hypertrophy, myofiber vacuolization, and clear pigmentation. Findings showed a significant up-regulation of cardiac Brain Natriuretic Peptide (BNP) along with marked down-regulation in hepatic FXR, cardiac FXR, and cardiac UCP2 and UCP3. However, the expression of caspase 3 in the cardiac tissue was not affected by BDL operation during 4 weeks. Conclusion: Expression of FXR as an upstream regulator of cellular redox status, besides the non-enzymatic ROS buffering defense system of cardiac UCPs, has a pivotal role in the pathogenesis of cirrhotic-induced cardiac abnormality in rats. |
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| کلیدواژههای انگلیسی مقاله |
Cardiomyopathy, cholestasis, Farnesoid-X-receptor, Liver Cirrhosis, Mitochondrial uncoupling proteins |
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| نویسندگان مقاله |
| Gholamreza Bayat
Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran|Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
| Seyed Ali Hashemi
Department of Pathology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
| Hosein Karim
Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran|Department of Cardiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
| Parviz Fallah
Department of Medical Laboratory Sciences, Faculty of Para-Medicine, Alborz University of Medical Sciences, Karaj, Iran
| Keshvad Hedayatyanfard
Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran|Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
| Mahnaz Bayat
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
| Azadeh Khalili
Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran|Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_19499.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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